Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat
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چکیده
منابع مشابه
Catechol-O-methyl transferase and schizophrenia.
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Gi...
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Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individuals. COMT activity is markedly reduced by a non-synonymous single-nucleotide polymorphism (SNP) ...
متن کاملGeneration of membrane-bound catechol-O-methyl transferase deficient mice with disctinct sex dependent behavioral phenotype.
Catechol-O-methyltransferase (COMT) has two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-MT), anchored to intracellular membranes. COMT is involved in the O-methylation of L-DOPA, dopamine and other catechols. The exact role of MB-COMT is still mostly unclear. We wanted to create a novel genetically modified mouse model that specifically lacks MB-COMT activ...
متن کاملNitrocatechol derivatives as inhibitors of catechol-O-methyltransferase.
Catechol-0-methyltransferase (EC 2.1.1.6; COMT) catalyses Sadenosylmethionine-dependent methylation of a variety of catechols and plays a role in terminating the activities of the catecholamine neurotransmitters dopamine and noradrenaline. Two isoenzymes, the soluble and membrane-bound forms (S-COMT and MB-COMT) are present in most tissues and although the former is more abundant, their differe...
متن کاملCatechol-o-methyl Transferase and Monoamine Oxidase Activity in the Ocular Tissues of Albino Rabbits.
The distribution of catechol-O-methyl transferase and monoamine oxidase activity in the ocular tissues of albino rabbits has been determined with a radioactive tracer assay. The distribution of the former varied in the different tissues within a restricted range whereas the distribution of monoamine oxidase activity exhibited larger variations. Sympathetic denervation did not appear to affect c...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2015
ISSN: 0007-1188
DOI: 10.1111/bph.13020