Pharmacological Potentials of Omega 3 Fatty Acid in Reduction of Atrial Fibrillation

Atrial fibrillation (AF) is the most common type of arrhythmia in general population with a prevalence that reaches one third patients arterial hypertension, diabetic and other risk factors. In atrial fibrillation, regular impulses produced by sinus node for normal heart beat are overwhelmed rapid electrical discharges atria adjacent parts pulmonary veins. Omega-3 polyunsaturated fatty acids (PUFAs), namely eicosapentaenoic acid (EPA) docosahexaenoic (DHA) permanent subjects interest relation to protection cardiovascular health prevention incidence both ventricular arrhythmias. It has been proposed possess anti-inflammatory properties can inhibit arrhythmogenic mechanisms. Potential Targets PUFAs Relevant Arrhythmias Prevention direct inhibition sarcolemmal ion channels & restoring cardiac connexion channels. Intake omega-3 significantly prevents occurrence AF. The purpose this review focus on novel cellular molecular effects PUFAs, context mechanisms factors involved development fibrillation.
 Keywords: Eicosapentaenoic acid, Docosahexaenoic Fibrillation, Polyunsaturated acids, Arrhythmias.