Pharmacological perioperative brain neuroprotection: nimodipine?
نویسندگان
چکیده
منابع مشابه
Pharmacological perioperative brain neuroprotection: a qualitative review of randomized clinical trials.
Perioperative cerebral damage may be associated with surgery and anaesthesia. Pharmacological perioperative neuroprotection is associated with conflicting results. In this qualitative review of randomized controlled clinical trials on perioperative pharmacological brain neuroprotection, we report the effects of tested therapies on new postoperative neurological deficit, postoperative cognitive ...
متن کاملPerioperative nimodipine and postoperative analgesia.
There is experimental evidence that nimodipine, an L-type dihydropiridine calcium channel blocker with relatively high blood-brain barrier penetration, enhances the antinociceptive properties of morphine. We tested the hypothesis that oral nimodipine taken preoperatively and 6 hourly for 48 h postoperatively would reduce visual analog scale pain scores and morphine consumption in morphine-naive...
متن کاملPharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury
Perinatal hypoxia-ischemia (HI) is an important cause of neonatal brain injury. Recent progress in the search for neuroprotective compounds has provided us with several promising drugs to reduce perinatal HI-induced brain injury. In the early stage (first 6 hours after birth) therapies are concentrated on prevention of the production of reactive oxygen species or free radicals (xanthine-oxidase...
متن کاملRecent advances in pharmacological neuroprotection
Treatment of brain ischaemic remains a challenging issue. During the last decade there has been much interest in the development of drugs with signifi cant neuroprotective effects against ischaemic injury in stroke patients. However, clinical trials have been disappointing as, so far, they all have failed to provide evidence for neuroprotection. Several reasons including lack of convincing expe...
متن کاملProphylactic Edaravone Prevents Transient Hypoxic-Ischemic Brain Injury: Implications for Perioperative Neuroprotection.
BACKGROUND AND PURPOSE Hypoperfusion-induced thrombosis is an important mechanism for postsurgery stroke and cognitive decline, but there are no perioperative neuroprotectants to date. This study investigated whether prophylactic application of Edaravone, a free radical scavenger already used in treating ischemic stroke in Japan, can prevent infarct and cognitive deficits in a murine model of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2014
ISSN: 0007-0912
DOI: 10.1093/bja/aet459