Pharmacological Interventions to Ameliorate Neuropathological Symptoms in a Mouse Model of Lafora Disease
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چکیده
منابع مشابه
Inhibiting glycogen synthesis prevents Lafora disease in a mouse model.
Lafora disease (LD) is a fatal progressive myoclonus epilepsy characterized neuropathologically by aggregates of abnormally structured glycogen and proteins (Lafora bodies [LBs]), and neurodegeneration. Whether LBs could be prevented by inhibiting glycogen synthesis and whether they are pathogenic remain uncertain. We genetically eliminated brain glycogen synthesis in LD mice. This resulted in ...
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ژورنال
عنوان ژورنال: Molecular Neurobiology
سال: 2015
ISSN: 0893-7648,1559-1182
DOI: 10.1007/s12035-015-9091-8