Pharmacological chaperones for the misfolded melanocortin-4 receptor associated with human obesity
نویسندگان
چکیده
منابع مشابه
Functional Rescue of Obesity-causing Human Melanocortin-4 Receptor Mutants: Insights for Pharmacological Chaperon Drugs
Copyright: © 2013 Dong B et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In the past decade, mammalian and human genetic studies revealed that the leptin-regulating pathway plays a critical role in cont...
متن کاملPoor cell surface expression of human melanocortin-4 receptor mutations associated with obesity.
The melanocortin-4 receptor (MC4R) plays an important role in the regulation of body weight in rodents. Mutations in the coding region of the MC4R are found more frequently in obese individuals, supporting the hypothesis that also in humans deficient melanocortin signaling may lead to obesity. Family studies that were carried out to demonstrate the relevance of single mutations for obesity were...
متن کاملAnti-melanocortin-4 receptor autoantibodies in obesity.
BACKGROUND The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients. METHODS The autoAbs were detected after screening of 216 patients' sera by using direct and inhibition ELISA with an N-terminal sequence of the MC4R. Binding to the native MC4R was evaluate...
متن کاملMelanocortin-4 receptor agonists for the treatment of obesity.
The identification of a highly efficacious anti-obesity agent remains an illusive goal. While many avenues of investigation have been pursued, none of the existing compounds claim much more than a 10% reduction in weight in humans (over a one year period with diet and exercise). Nonetheless, the potential reward for fulfilling this unmet medical need has kept interest levels high in the researc...
متن کاملa 3d model for human melanocortin 4 receptor refined with molecular dynamics simulation
despite a quite short early history, computational drug design and discovery methods can now be efficient in reducing costs and speeding up drug developing procedure. melanocortin-4 receptor (mc4r) is a g protein-coupled receptor implicated in the regulation of body weight. despite its clinical reputation, there is a lack of in-depth knowledge about structure and behavior of mc4r in lipid bilay...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2017
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2017.03.001