Pharmacological Approaches to Managing Migraine and Associated Comorbidities-Clinical Considerations for Monotherapy Versus Polytherapy

Monotherapy or polytherapy for epilepsy?

Monotherapy has been promoted as the ideal in epilepsy treatment because of reduced side effects, absence of drug interactions, better compliance, lower cost and, in many cases, improved seizure control compared to polytherapy. The question of monotherapy vs. polytherapy has assumed increasing importance with the availability of multiple new antiepileptic drugs (AEDs), initially tested as add-o...

Rational conversion from antiepileptic polytherapy to monotherapy.

For patients with epilepsy, the goal of treatment is to achieve seizure freedom with minimal or no adverse events. Around 60%-70% of newly diagnosed patients will achieve this goal with single antiepileptic drug (AED) therapy, and there is universal agreement that prescription of a single agent constitutes best practice for such patients. For the 30%-40% of patients with poorly controlled epile...

Monotherapy or Polytherapy for Childhood Epilepsies? Background

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Transitional Polytherapy: Tricks of the Trade for Monotherapy to Monotherapy AED Conversions

The goal of epilepsy therapy is to help patients achieve seizure freedom without adverse effects. While monotherapy is preferable in epilepsy treatment, many patients fail a first drug due to lack of efficacy or failure to tolerate an initial medication, necessitating an alteration in therapy. Sudden changes between monotherapies are rarely feasible and sometimes deleterious given potential haz...

Clinical Guidelines: Managing Common Coinfections and Comorbidities