Pharmacological activity of the novel loop-diuretic Torasemide. —Diuretic action in normal animals —
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چکیده
منابع مشابه
Gender is an important determinant of the disposition of the loop diuretic torasemide.
Signals from pharmacovigilance studies indicate that women are at higher risk for adverse drug reactions (ADRs) due to diuretics. Despite the long-term use of torasemide, there are few studies investigating gender differences of torasemide pharmacokinetics in the hospital setting. Therefore, torasemide pharmacokinetics were investigated in 90 patients (45 women, 45 men) during steady-state cond...
متن کاملTorasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy.
Torasemide is a long-acting loop diuretic that combines the effects of both furosemide and spironolactone. It has been reported that torasemide may block the renin-angiotensin-aldosterone system and therefore it might attenuate myocardial remodeling accompanied by left ventricular dysfunction. However, nothing is known about the effect of torasemide on myocardial remodeling in a rat model in wh...
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As the molecular revolution continues to inform a deeper understanding of disease mechanisms and pathways, there exist unprecedented opportunities for translating discoveries at the bench into novel therapies for improving human health. Despite the availability of several different classes of antihypertensive medications, only about half of the 67 million Americans with hypertension manage thei...
متن کاملLoop diuretic efficiency: a metric of diuretic responsiveness with prognostic importance in acute decompensated heart failure.
BACKGROUND Rather than the absolute dose of diuretic or urine output, the primary signal of interest when evaluating diuretic responsiveness is the efficiency with which the kidneys can produce urine after a given dose of diuretic. As a result, we hypothesized that a metric of diuretic efficiency (DE) would capture distinct prognostic information beyond that of raw fluid output or diuretic dose...
متن کاملTwice daily loop diuretic dosing time
Torsemide is the first loop diuretic in the pyridine sulfonylurea class. of prescribing furosemide b.i.d., a more appropriate dosing seems to be fourtimes a day.. Moreover, the once daily (q.d.) dosing of torsemide offers improved patient . (furosemide) is a potent diuretic which, if given in excessive amounts, can lead to a chloride not only in the proximal and distal tubules but also in the l...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)55936-4