Pharmacological Actions of Multi-Target-Directed Evodiamine

Pharmacological actions of multi-target-directed evodiamine.

Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention has been paid to beneficial effects in insults involving cancer, obesity, nociception, inflammation, cardiovascular diseases, Alzheimer's disease, infectious diseases and thermo-regulative effects. Evodiamine ha...

Pharmacological actions of cannabinoids.

Mammalian tissues express at least two types of cannabinoid receptor, CB1 and CB2, both G protein coupled. CB1 receptors are expressed predominantly at nerve terminals where they mediate inhibition of transmitter release. CB2 receptors are found mainly on immune cells, one of their roles being to modulate cytokine release. Endogenous ligands for these receptors (endocannabinoids) also exist. Th...

Some pharmacological actions of alcohol.

The contribution which alcohol may make to a man's nutrition varies considerably. Alcohol is not an essential dietary constituent, but it is commonly consumed, and unlike most foods it has notable subjective and objective effects in quantities which contribute trivially to the total daily calories. Moderate drinkers are much commoner than those who consume to excess, and it will therefore be mo...

Actions of a separately strict cpo-monoid on pointed directed complete posets

‎ In the present article‎, ‎we study some categorical properties of the category {$bf‎ Cpo_{Sep}$-$S$} of all {separately strict $S$-cpo's}; cpo's equipped with‎ a compatible right action of a separately strict cpo-monoid $S$ which is‎ strict continuous in each component‎. ‎In particular‎, we show that this category is reflective and coreflective in the‎ category of $S$-cpo's‎, ‎find the free a...

Goal-directed actions