Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV
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چکیده
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assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
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BACKGROUND HIV-infected individuals, even well controlled with combined antiretroviral therapy (cART), have systemic inflammation and comorbidities. Substance P (SP) is an undecapeptide, which mediates neurotransmission and inflammation through its cognate neurokinin 1 receptor (NK1R). Plasma SP levels are elevated in HIV-infected individuals. The FDA-approved antiemetic aprepitant, an NK1R ant...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2016
ISSN: 1479-5876
DOI: 10.1186/s12967-016-0904-y