Pharmacokinetics of rectal compared to intramuscular paracetamol in children undergoing minor surgery

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Pharmacokinetics of rectal compared to intramuscular paracetamol in children undergoing minor surgery

Objectives: Although paracetamol is a widely accepted and safe analgesic, guidelines regarding its definite analgesic dose are lacking. This study was, therefore, undertaken to compare the pharmacokinetics of paracetamol when administered by two routes, viz, intramuscular and rectal, in children undergoing minor surgery. Design: Randomized, controlled, assessor-blind, comparative clinical trial...

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Pharmacokinetics of paracetamol after cardiac surgery.

Plasma concentration was measured after rectal and nasogastric administration of paracetamol 15 mg/kg to 28 febrile children aged between 9 days to 7 years who had undergone cardiac surgery. After equivalent doses, rectal administration in neonates and children on the first postoperative day was found to produce plasma concentrations below the therapeutic range with higher concentrations after ...

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Rectal paracetamol in small children with fever.

37 febrile children aged between 3 months and 6 years were treated with paracetamol in a dose of 15--20 mg/kg by either oral elixir or rectal suppository. The rectal route was found to have an equal antipyretic effect and offers a practical alternative in those children for whom the oral route is not possible.20

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Pharmacokinetics of rectal ketamine in children.

We have studied the pharmacokinetics of ketamine administered rectally in a dose of 10 mg kg-1 to five children aged 6-9 yr and mean weight 28.80 (SD 6.55) kg. An acceptable level of anaesthesia was not obtained in any patient. Despite this, the degree of analgesia obtained was good and no child required further administration of analgesics during the postoperative period. Tolerance to the supp...

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Comparison of Emergence Time in Children Undergoing Minor Surgery According to Anesthetic: Desflurane and Sevoflurane

PURPOSE In earlier analyses, desflurane has been shown to reduce average extubation time and the variability of extubation time by 20% to 25% relative to sevoflurane in adult patients. We undertook this study to determine which agents prompt less recovery time in pediatric patients undergoing minor surgery. MATERIALS AND METHODS After obtaining Institutional Review Board approval, we retrospe...

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ژورنال

عنوان ژورنال: Indian Journal of Pharmacology

سال: 2007

ISSN: 0253-7613

DOI: 10.4103/0253-7613.36537