Pharmacokinetics of fosmidomycin, a new phosphonic acid antibiotic
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چکیده
منابع مشابه
In vitro synergism of FR-31564, a new phosphonic acid antibiotic.
Against most test strains of Gram-negative bacilli, the in vitro effect of FR-31564 together with beta-lactam antibiotics or trimethoprim was strongly synergistic; with tetracycline and nalidixic acid the effect was additive; and with gentamicin and sulfamethoxazole the effect was additive or antagonistic. FR-31564 was markedly synergistic with beta-lactam antibiotics against beta-lactam antibi...
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The molecular structure of the stable conformation of phosphonic acid in gas phase has beencomputed by employing complete geometry optimization in Density Functional Theory(DFT) methods. The methods used for calculations are B3LYP, BP86 and B3PW91 that havebeen studied in two series of basis sets: D95** and 6-31+G(d,p) for hydrogen and oxygenatoms; LANL2DZ for phosphorus. Bond lengths and angle...
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glucose, 1.0 % peptone, 1.0 % corn steep liquor, 0.2 /00 KH2PO4 and 0.1 % MgSO4 (pH 6.5) for 66 hours at 26°C. Botric acid principally existed in the mycelia, the activity was bio-assayed using Candida albicans as a test organism on SABOURAUD'S glucose medium. The cultured broth (180 liters) was filtered, and the mycelial cake was extracted twice with each 20liters of acetone. The extract was c...
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The phosphonic acid functional group, which is characterized by a phosphorus atom bonded to three oxygen atoms (two hydroxy groups and one P=O double bond) and one carbon atom, is employed for many applications due to its structural analogy with the phosphate moiety or to its coordination or supramolecular properties. Phosphonic acids were used for their bioactive properties (drug, pro-drug), f...
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The pharmacokinetic properties of amoxicillin and clavulanic acid when used alone or in combination may be different and show interaction between these two agents that might decrease the absolute bioavailability of clavulanic acid. In an open, randomized, replicated Latin square under fasting condition, pharmacokinetics of new formulations of amoxicillin/clavulanic acid were compared with...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1982
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.21.2.224