Pharmacokinetics of a ternary conjugate based pH-responsive 10-HCPT prodrug nano-micelle delivery system
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چکیده
منابع مشابه
A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting
We synthesized a pH-responsive conjugate of 10-hydroxycamptothecin-thiosemicarbazide-linear polyethylene glycol 2000 (PEG2000). The conjugate was confirmed by matrix-assisted laser desorption time of flight mass spectrometry, 1H NMR, and 13C NMR. The water solubility of the prodrug was increased by over 3,000 times; much longer body circulation time, higher tumor-targeting ability, and reduced ...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2017
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2017.05.005