Pharmacokinetics, biodistribution and antitumour effects of Sclerotium rolfsii lectin in mice
نویسندگان
چکیده
منابع مشابه
The crystal structure of the sclerotium rolfsii lectin
Lectins are non-enzymic carbohydrate binding proteins present in plants, bacteria, fungi, and animals, which preferentially bind reversibly to specific carbohydrate structures whether free in solution or on cell surfaces and play important role in cell recognition. Sclerotium rolfsii, a soil borne plant pathogenic fungus capable of forming fruiting bodies referred to as sclerotial bodies, secre...
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Aim: Oral cancer is a major health problem in India associated with significant morbidity and mortality. Due to the absence of truly specific symptoms, the early diagnosis of oral cancer is quite challenging. Aberrant glycosylation of cell surface glycoconjugates is an important feature of malignant changes. Abnormal glycosylation in cancer leads to formation of altered glycoconjugates such as ...
متن کاملMolecular Cloning, Carbohydrate Specificity and the Crystal Structure of Two Sclerotium rolfsii Lectin Variants.
SRL is a cell wall associated developmental-stage specific lectin secreted by Sclerotium rolfsii, a soil-born pathogenic fungus. SRL displays specificity for TF antigen (Galβ1→3GalNAc-α-Ser//Thr) expressed in all cancer types and has tumour suppressing effects in vivo. Considering the immense potential of SRL in cancer research, we have generated two variant gene constructs of SRL and expressed...
متن کاملOccurrence of Sclerotium Rot in Allium tuberosum Caused by Sclerotium rolfsii in Korea
In this study, we characterized sporadically occurring sclerotium rot caused by Sclerotium rolfsii in Chinese chive (Allium tuberosum Roth.) in farm fields in Sacheon, Korea. The initial symptom of the disease was water-soaked, which progressed to rotting, wilting, blighting, and eventually death. Further, mycelial mats spread over the lesions near the soil line, and sclerotia formed on the sca...
متن کاملImmunolocalization and functional role of Sclerotium rolfsii lectin in development of fungus by interaction with its endogenous receptor.
Many fungi are known to secrete lectins, but their functional roles are not clearly understood. Sclerotium rolfsii, a soilborne plant pathogenic fungus capable of forming fruiting bodies called sclerotial bodies, secrete a cell wall-associated Thomsen-Friedenreich antigen-specific lectin. To understand the functional role of this lectin, we examined its occurrence and expression during developm...
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ژورنال
عنوان ژورنال: Oncology Reports
سال: 2017
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.2017.5545