Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers
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چکیده
منابع مشابه
Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep.
BACKGROUND CNS 7056 is a new short-acting esterase-metabolized benzodiazepine. We report the first pharmacokinetic (PK) and pharmacodynamic (PD) study of CNS 7056 and its inactive metabolite CNS 7054 in sheep. METHODS The stability of CNS 7056 in blood samples was examined ex vivo. Six sheep were prepared with physiological instrumentation, and were given doses of 0.37, 0.74, and 1.47 mg kg(-...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2020
ISSN: 0003-3022
DOI: 10.1097/aln.0000000000003102