Pharmacokinetics and Pharmacodynamics of Hyaluronan Infused into Healthy Human Volunteers
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Pharmacokinetics and Pharmacodynamics of Hyaluronan Infused into Healthy Human Volunteers
The pharmacodynamics and elimination kinetics of escalating doses (1.5-12 mg/kg) of hyaluronan (HA) infusions were studied in healthy human volunteers. Metabolic breakdown of serum HA and associated adverse events were monitored throughout the study. The HA-binding capacities of circulating CD4+ and CD8+ T lymphocytes, CD19+ Blymphocytes and CD14+ peripheral blood monocytes (PBMC) were also qua...
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ژورنال
عنوان ژورنال: The Open Drug Metabolism Journal
سال: 2009
ISSN: 1874-0731
DOI: 10.2174/1874073100903010043