Pharmacokinetics and bioavailability of oral ifosfamide
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چکیده
منابع مشابه
Bioavailability and pharmacokinetics of oral meloxicam in llamas
BACKGROUND South American camelids in the United States have rapidly developed into an important agricultural industry in need of veterinary services. Pain management is challenging in camelids because there are no drugs currently approved by the U.S. Food and Drug Administration for use in these species. Dosage regimens used for many therapeutic drugs have been extrapolated from other ruminant...
متن کاملComparative pharmacokinetics and alkylating activity of fractionated intravenous and oral ifosfamide in patients with bronchogenic carcinoma.
20 patients with advanced non-small cell lung cancer were treated with ifosfamide and mesna 1.5 g/m2 daily for 5 days; 10 received the drug by mouth and 10 i.v. Both schedules resulted in a reduction in the elimination half-life with an increased total and nonrenal clearance of ifosfamide over the 5-day period. Oral administration resulted in an unacceptably high incidence of encephalopathy(5/1...
متن کاملComparative pharmacokinetics of oral and intravenous ifosfamide/mesna/methylene blue therapy.
Oral treatment with ifosfamide results in dose-limiting encephalopathy. Methylene blue is effective in reversal and prophylaxis of this side effect. In the present study, the pharmacokinetics of ifosfamide after iv and po therapy in combination with prophylactic administration of methylene blue were investigated. Nine patients with metastatic non-small cell lung cancer were treated by a combina...
متن کاملPharmacokinetics of digoxin: interpreting bioavailability.
Three subjects were first given a digoxin tablet in the fasting state and subsequently received the same formulation in the fed state, to simulate a spurious oral bioavailability difference. As expected, when measured by peak serum digoxin concentration as well as by area under the serum digoxin concentration-time curve the bioavailability of digoxin appeared to be higher in the fasting state t...
متن کاملComparison of the bioavailability and pharmacokinetics of oral methylergometrine in men and women.
OBJECTIVE To assess and compare the pharmacokinetics and bioavailability of methylergometrine (ME) in men and non-pregnant women. DESIGN A cross-over design was used for an oral dose of 0.125 mg and an intravenous dose of 0.200 mg of ME in 6 men and 6 non-pregnant women (parallel-design in gender). RESULTS After intravenous administration, the pharmacokinetic profile of ME was described wit...
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ژورنال
عنوان ژورنال: Journal of Cancer Research and Clinical Oncology
سال: 1986
ISSN: 0171-5216,1432-1335
DOI: 10.1007/bf02579884