Pharmacokinetically guided optimum adaptive dose selection in early phase clinical trials
نویسندگان
چکیده
منابع مشابه
Adaptive dose insertion in early phase clinical trials.
BACKGROUND AND PURPOSE We propose to adaptively insert new doses during the course of a dose-finding trial when none of the prespecified doses in the trial are acceptable, for example, have tolerable toxicity. METHODS Our procedure uses an activation rule to determine whether a new dose is needed and an inverse dose-response algorithm to estimate new doses to be inserted into the trial. RES...
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ژورنال
عنوان ژورنال: Computational Statistics & Data Analysis
سال: 2017
ISSN: 0167-9473
DOI: 10.1016/j.csda.2017.02.009