Pharmacokinetic Study of Perioperative Intravenous Ifosfamide

Pharmacokinetic Study of Perioperative Intravenous Ifosfamide

The use of cancer chemotherapy and hyperthermia as part of a surgical procedure in the management of patients with peritoneal carcinomatosis has gained prominence in recent years with selected patients showing benefit. Patients with peritoneal surface malignancy following cancer resection were treated with intraperitoneal hyperthermic (41.5-42.5°C) cisplatin and doxorubicin combined with the in...

Does intraosseous equal intravenous? A pharmacokinetic study.

STUDY OBJECTIVE Despite the growing popularity of intraosseous infusion for adults in emergency medicine, to date there has been little research on the pharmacokinetics of intraosseously administered medications in humans. The objective of the study was to compare the pharmacokinetics of intraosseous vs intravenous administration of morphine sulfate in adults. METHODS The study followed a pro...

Treatment of ifosfamide encephalopathy with intravenous thiamin.

Encephalopathy is a well-known side effect of IFOS. This syndrome develops in 10% of patients exposed to the drug and usually disappears after stopping therapy, although some patients may die without recovery (1). It has been proposed that IFOS metabolites may interfere with the function of flavoproteins, leading to the observed CNS disturbances (2), and therapy with methylene blue has been suc...

Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations.

BACKGROUND Ifosfamide, which is routinely given to treat a variety of solid tumours in children, causes serious nephrotoxicity in treated children. Previous in vitro studies have shown that depletion of intracellular glutathione can enhance ifosfamide nephrotoxicity. Presently, there is no therapeutic agent that can prevent ifosfamide nephrotoxicity. We have recently shown that N-acetylcysteine...

Perioperative Use of Intravenous Lidocaine.