Pharmacokinetic Study of Lappaconitine Hydrobromide Transfersomes in Rats by LC-MS

Pharmacokinetic Study of Lappaconitine Hydrobromide Transfersomes in Rats by LC-MS

Volume 4 • Issue 3 • 1000217 Pharmaceut Anal Acta ISSN: 2153-2435 PAA, an open access journal *Corresponding author: Wen-sheng Zheng, Institute of Materia Medica, Chinese Academy of Medical Sciences& Peking Union Medical College, Beijing City Key Laboratory of Drug Delivery Technology and Novel Formulations, Beijing 100050, People’s Republic of China, Tel: +86 010 63165233; Fax: +86 010 6301775...

Determination of Cremophor EL in Rat Plasma by LC-MS/MS: Application to a Pharmacokinetic Study

Polyoxyethyleneglycerol triricinoleate (Cremophor EL; CrEL) is a liquid product formed by the reaction of ethylene oxide with castor oil at a molar ratio of 35:1 [1]. CrEL is used as a excipient in formulations for the solubilization of various hydrophobic drugs including anesthetics [2], antineoplastic agents [2,3] immunosuppressive agents [4], analgesics [5,6] vitamins [7] and new synthetic w...

Quantification of tolvaptan in rabbit plasma by LC–MS/MS: Application to a pharmacokinetic study☆

A sensitive, selective and high-throughput liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for the quantitation of tolvaptan in rabbit plasma. Sample clean-up involved liquid-liquid extraction (LLE) and chromatography was performed on Zorbax SB C18 analytical column (50 mm×2.1 mm, 3.5 µm) using 0.1% formic acid:methanol (20:80, v/v) as the mobile...

Simultaneous determination and pharmacokinetic study of metformin and pioglitazone in dog plasma by LC-MS-MS.

A high-performance liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of metformin (MET) and pioglitazone (PIO) in dogs. To increase the reliability of the method, moroxydine (IS-1) and rosiglitazone (IS-2) were used as internal standards for MET and PIO, respectively. The analytes were extracted from beagle dog plasma by a one-step protein pr...

Evaluation of Microdosing to Assess Pharmacokinetic Linearity in Rats using LC/MS/MS