Pharmacokinetic evaluation of proguanil: a probe phenotyping drug for the mephenytoin hydroxylase polymorphism
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چکیده
منابع مشابه
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15 صفحه اولProguanil metabolism in relation to S-mephenytoin oxidation in a Turkish population.
The oxidation of proguanil was studied in 89 unrelated healthy Turkish volunteers after administration of proguanil (single dose, 200 mg, orally). Based on the distribution of the ratio of proguanil to cycloguanil excreted in urine, and using an antimode value of 15, the prevalence of poor metabolizers in a Turkish population was estimated to be 5.6% (95% confidence interval 2.0%-17.3%) which w...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1996
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1996.tb00179.x