Pharmacogenomics in Personalized Drug Therapy
نویسندگان
چکیده
منابع مشابه
personalized medicine: pharmacogenomics and drug development
personalized medicine aims is to supply the proper drug to the proper patient within the right dose. pharmacogenomics (pgx) is to recognize genetic variants that may influence drug efficacy and toxicity. all things considered, the fields cover a wide area, including basic drug discovery researches, the genetic origin of pharmacokinetics and pharmacodynamics, novel drug improvement, patient gene...
متن کاملPharmacogenomics in Personalized Medicine and Drug Metabolism
1 Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, No. 250, Wuxing Street, Xinyi District, Taipei 110, Taiwan 2Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, No. 111, Section 3, Xinglong Road, Wenshan District, Taipei 116, Taiwan 3Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical Universit...
متن کاملPharmacogenomics and individualized drug therapy.
Pharmacogenetics deals with inherited differences in the response to drugs. The best-recognized examples are genetic polymorphisms of drug-metabolizing enzymes, which affect about 30% of all drugs. Loss of function of thiopurine S-methyltransferase (TPMT) results in severe and life-threatening hematopoietic toxicity if patients receive standard doses of mercaptopurine and azathioprine. Gene dup...
متن کاملPharmacogenomics of adverse drug reactions: implementing personalized medicine.
Pharmacogenomics aims to investigate the genetic basis of inter-individual differences in drug responses, such as efficacy, dose requirements and adverse events. Research in pharmacogenomics has grown over the past decade, evolving from a candidate-gene approach to genome-wide association studies (GWASs). Genetic variants in genes coding for drug metabolism, drug transport and more recently hum...
متن کاملPharmacogenomics and Personalized Medicine
Pharmacogenetics is a newer branch of pharmacological sciences studying the relationship between genetic predisposition of an individual and his ability to metabolize a drug. It helps understand why some individuals respond to drugs and others do not, why some individuals require higher or lower doses to achieve an optimal therapeutic response, and tries to help the physician identify those pat...
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ژورنال
عنوان ژورنال: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
سال: 2013
ISSN: 1346-342X,1882-1499
DOI: 10.5649/jjphcs.39.327