Pharmacogenomics and Translational Research
نویسندگان
چکیده
منابع مشابه
The role of pharmacogenetics and pharmacogenomics in improving translational medicine.
The approval of new medicines has slowed significantly over the past years. In order to accelerate the development of new compounds, novel approaches in drug development are required. Translational medicine or research, an emerging discipline on the frontier of basic science and medical practice, has the potential to enhance the speed and efficiency of the drug development process through the u...
متن کاملEvolving research and stakeholder perspectives on pharmacogenomics.
THE PAST DECADE HAS BEEN A TIME OF IMPORTANT change in pharmacogenomics. There is an increasingly clear understanding of the relationship between genetic variation and drug response, lowcost testing technologies are becoming available, and pharmacogenomics is playing an increasing role in drug development. Key stakeholders in the US health care system are responding to these changes in various ...
متن کاملePGA: A Web-Based Information System for Translational Pharmacogenomics
One of the challenges that arise from the advent of personal genomics services is to efficiently couple individual data with state of the art Pharmacogenomics (PGx) knowledge. Existing services are limited to either providing static views of PGx variants or applying a simplistic match between individual genotypes and existing PGx variants. Moreover, there is a considerable amount of haplotype v...
متن کاملBasic and translational research
Weinblatt ME, Bingham CO, Mendelsohn AM, et al. Ann Rheum Dis (2012). doi:10.1136/annrheumdis-2012-201411 1 of 9 and anti-TNF-experienced4 patients with RA when administered monthly via subcutaneous injection. Intravenous administration of golimumab every 12 weeks (q12 weeks) was previously assessed in a phase 3 trial in patients with RA, with persistent disease despite MTX therapy.5 While the ...
متن کاملBasic and translational research
1Division of Rheumatology and Immunogenetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA 2Department of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA 3Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA 4Department of Medicine/ Rheumatolog...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 2004
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.35.3_124