منابع مشابه
Pediatric information in drug product labeling.
To the Editor: The dearth of information on drugs for children led to children being called “therapeutic orphans.” In 1975, Wilson determined that 78% of drug labeling had inadequate pediatric information. In 1999, Wilson summarized 25 years of efforts to get pediatric information into labeling and extended his analysis. In the decade after Wilson’s review, regulations and legislation have led ...
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Pharmacogenetics deals with inherited differences in the response to drugs. The best-recognized examples are genetic polymorphisms of drug-metabolizing enzymes, which affect about 30% of all drugs. Loss of function of thiopurine S-methyltransferase (TPMT) results in severe and life-threatening hematopoietic toxicity if patients receive standard doses of mercaptopurine and azathioprine. Gene dup...
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personalized medicine aims is to supply the proper drug to the proper patient within the right dose. pharmacogenomics (pgx) is to recognize genetic variants that may influence drug efficacy and toxicity. all things considered, the fields cover a wide area, including basic drug discovery researches, the genetic origin of pharmacokinetics and pharmacodynamics, novel drug improvement, patient gene...
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OBJECTIVES This study sought to assess the value of the Health Level 7/U.S. Food and Drug Administration Structured Product Labeling (SPL) drug knowledge representation standard and its associated terminology sources for drug-intolerance (allergy) decision support in computerized provider order entry (CPOE) systems. DESIGN The Regenstrief Institute CPOE drug-intolerance issue detection system...
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Drug-drug interactions (DDIs) are defined as clinically meaningful alterations in the exposure and response to a drug (called object drug) that has occurred as a result of the co-administration of another drug (called precipitant drug). According a 2011 study, drug-drug interactions (DDIs) are responsible for roughly 220,000 hospital admissions per year (Percha and Altman 2013). However, this n...
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ژورنال
عنوان ژورنال: Hospital Pharmacy
سال: 2003
ISSN: 0018-5787,1945-1253
DOI: 10.1177/001857870303800606