منابع مشابه
Pharmacogenomic Biomarkers
Pharmacogenomic biomarkers hold great promise for the future of medicine and have been touted as a means to personalize prescriptions. Genetic biomarkers for disease susceptibility including both Mendelian and complex disease promise to result in improved understanding of the pathophysiology of disease, identification of new potential therapeutic targets, and improved molecular classification o...
متن کاملA European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics
Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is inco...
متن کاملCorrection: A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics
[This corrects the article DOI: 10.1371/journal.pone.0162866.].
متن کاملNetwork-based identification of microRNAs as potential pharmacogenomic biomarkers for anticancer drugs
As the recent development of high-throughput technologies in cancer pharmacogenomics, there is an urgent need to develop new computational approaches for comprehensive identification of new pharmacogenomic biomarkers, such as microRNAs (miRNAs). In this study, a network-based framework, namely the SMiR-NBI model, was developed to prioritize miRNAs as potential biomarkers characterizing treatmen...
متن کاملPharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin
Nephrotoxicity is a dose limiting side effect associated with the use of cisplatin in the treatment of solid tumors. The degree of nephrotoxicity is dictated by the selective accumulation of cisplatin in renal tubule cells due to: (1) uptake by organic cation transporter 2 (OCT2) and copper transporter 1 (CTR1); (2) metabolism by glutathione S-transferases (GSTs) and γ-glutamyltransferase 1 (GG...
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ژورنال
عنوان ژورنال: Disease Markers
سال: 2002
ISSN: 0278-0240,1875-8630
DOI: 10.1155/2002/341708