منابع مشابه
I-33: Pharmacogenetics of Reproductive Medicine
Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...
متن کاملImpact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose
Thiopurines are widely used as anticancer and immunosuppressive agents. However, life-threatening myelotoxicity has been noticed and largely explained by genetic variations, including NUDT15 polymorphisms (e.g., rs116855232). In this study, we conduct a meta-analysis to investigate the impact of rs116855232 on thiopurines-induced myelotoxicity susceptibility (1752 patients from 7 independent co...
متن کاملUse of thiopurines in inflammatory bowel disease.
The use of thiopurines as immunosuppression for the treatment of refractory or chronic active inflammatory bowel disease is established for both Crohn's disease and ulcerative colitis. Nevertheless, many questions remain concerning the optimal treatment regimens of azathioprine, 6-mercaptopurine and thioguanine. We will briefly summarize dose recommendations, indications for thiopurine therapy ...
متن کاملExperimental Pharmacogenetics
Furthermore, Dr. Moulder is able to make the reader realize that the problem has considerable theoretical and practical value and is not just an exercise in semantics. It is a stimulating book. Investigators in a wide variety of fields will find this short volume an extremely useful reference book. The purpose of the monograph was to bring together the known biochemical and structural inherited...
متن کاملCardiovascular pharmacogenetics.
Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical variation seen in response to pharmacotherapeutic drugs. This affects the likelihood of experiencing adverse drug reactions and also of achieving therapeutic success. In this paper, ...
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ژورنال
عنوان ژورنال: Cancer Drug Resistance
سال: 2019
ISSN: 2578-532X
DOI: 10.20517/cdr.2019.004