Pharmacogenetics and polymorphism: future tools for optimizing therapeutic efficacy
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency.
Pharmacogenetics is the study of the linkage between an individual's genotype and that individual's ability to metabolize a foreign compound. Differences in metabolism of therapeutics can lead to severe toxicity or therapeutic failure by altering the relation between dose and blood concentration of the pharmacologically active drug. Phenotypes exhibiting poor and ultraextensive metabolism resul...
متن کاملRecommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations
Although tuberculosis is largely a curable disease, it remains a major cause of morbidity and mortality worldwide. Although the standard 6-month treatment regimen is highly effective for drug-susceptible tuberculosis, the use of multiple drugs over long periods of time can cause frequent adverse drug reactions. In addition, some patients with drug-susceptible tuberculosis do not respond adequat...
متن کاملPharmacogenetics: past, present and future.
The subject area of pharmacogenetics, also known as pharmacogenomics, has a long history. Research in this area has led to fundamental discoveries, which have helped our understanding of the reasons why individuals differ in the way they handle drugs, and ultimately in the way they respond to drugs, either in terms of efficacy or toxicity. However, not much of this knowledge has been translated...
متن کاملPharmacogenetics: an Emerging Therapeutic Option for Bangladesh
From socioeconomic point of view adverse drug reactions (ADRs) present a challenging and expensive public health problem worldwide. Most important factors involved in this life threatening events are false diagnosis, failure of treatment, lack of proper patient counseling, lack of knowledge regarding medication use and polypharmacy. Pharmacogenetic research explores genetic variability between ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bangladesh Journal of Physiology and Pharmacology
سال: 2014
ISSN: 2408-8439,1561-1566
DOI: 10.3329/bjpp.v26i1-2.19966