منابع مشابه
Pharmacogenetics and Pharmacogenomics
The individual differences in response to administered substance (medicament) were observed throughout the whole history of humankind. Pythagoras is thought to be one of the first to observe pharmaco/nutrigenetic interaction as he found out that only some people will get sick after eating fava beans, but others will not. It took approximately 2400 years to elucidate the basis of this observatio...
متن کاملAdvances in pharmacogenetics and pharmacogenomics.
Large differences among normal human subjects in the efficacy and safety of many therapeutic agents are caused by genetically controlled polymorphisms of drug-metabolizing enzymes, drug transporters, and drug receptors. Development of pharmacogenomics as a new field has accelerated progress in pharmacogenetics by elucidating at the level of the human genome the inherited basis for those large i...
متن کاملPharmacogenetics, pharmacogenomics, and individualized medicine.
Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics ...
متن کاملPharmacogenetics, pharmacogenomics and airway disease
The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmacogenetics and pharmacogenomics. Considerable inter-individual variation exists at the DNA level in targets for medication, and variability in response to treatment may, in part, be determi...
متن کاملPharmacogenetics and pharmacogenomics: are they still promising?
In the last several years pharmacogenetics and pharmacogenomics have attracted the interest of the scientific community and of important pharmaceutical groups. What is the consequence for medicine and for the pharmaceutical industry? What has emerged from this investment, and what can we expect for the future? As with many new technologies, pharmacogenetics and pharmacogenomics were first adapt...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2001
ISSN: 0306-5251
DOI: 10.1046/j.0306-5251.2001.01498.x