Pharmacogenetic studies of thiopurine methyltransferase genotype‐phenotype concordance and effect of methotrexate on thiopurine metabolism
نویسندگان
چکیده
منابع مشابه
Pharmacogenetic studies of thiopurines – focus on thiopurine methyltransferase
POPULÄRVETENSKAPLIG SAMMANFATTNING (SWEDISH) PAPERS IN THE PRESENT THESIS
متن کاملThiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase.
Thiopurine drugs are used to treat patients with neoplasia and autoimmune disease as well as transplant recipients. These agents are metabolized, in part, by S-methylation catalyzed by thiopurine methyltransferase (TPMT). The discovery nearly two decades ago that levels of TPMT activity in human tissues are controlled by a common genetic polymorphism led to one of the best examples of the poten...
متن کاملPharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy.
Most medications exhibit wide interpatient variability in their efficacy and toxicity. For many medications, these interindividual differences result in part from polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and/or drug targets (eg, receptors, enzymes). Pharmacogenomics is a burgeoning field aimed at elucidating the genetic basis of differences in drug efficacy ...
متن کاملThe effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs.
Although the thiopurine drugs 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are well established agents for the treatment of leukemia, controversies remain regarding their main mode of action. Previous evidence has suggested that although 6-TG exerts a cytotoxic effect through incorporation of 6-thioguanine nucleotides into newly synthesized DNA (DNA-TGN), an important component of the mode ...
متن کاملAssessment of Thiopurine–based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia
For the past half century, thiopurines have earned themselves a reputation as effective anti-cancer and immunosuppressive drugs. Thiopurine S-methyltransferase (TPMT) is involved in the metabolism of all thiopurines and is one of the main enzymes that inactivates mercaptopurine. 6-MP is now used as a combination therapies for maintenance therapy of children with acute lymphocytic leukemia (A...
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ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2020
ISSN: 1742-7835,1742-7843
DOI: 10.1111/bcpt.13483