Phage Display Screening for Alba Superfamily Proteins from the Human Malaria Parasite, Plasmodium falciparum Reveals a High Level of Association with Protein Modification Pathways and Hints at New Drug Targets

A 2016 study estimated that over 3 billion people are currently at risk of contracting malaria. Although a wide variety medications available to treat malaria, the parasites have started exhibit resistance many commonly used therapeutics necessitating push for new investigations identify novel drug targets. In this study, nucleic acid-binding Alba superfamily proteins human malaria parasite, Plasmodium falciparum were investigated interacting protein motifs. high-throughput molecular screening technique, phage display, coupled with next-generation sequencing was applied assess large data sets. Four P. which appear distinct roles in parasite biology based on results work. The majority peptide motifs identified from display involved post-translational modification pathways, thus suggesting parasite-specific gene regulatory mechanisms could serve as targets therapeutics. This found 18 potentially strong interactions one or more falciparum. Considering fraction modification-related work, pathways good target treatment.