Ph-Negative Chronic Myeloproliferative Neoplasms – Population Analysis, a Single Center 10-years’ Experience

Second malignancies in philadelphia-negative myeloproliferative neoplasms-single-center experience.

AIM The aim of this work was to retrospectively analyze patients with Philadelphia-negative myeloproliferative neoplasms through evaluation of frequency and characteristics of second malignancies (other than acute leukaemia and myelodysplastic syndrome). PATIENTS AND METHODS Records of 172 patients were reviewed; an analysis was performed on data from 66 patients treated with hydroxyurea, 105...

Philadelphia-negative chronic myeloproliferative neoplasms

Chronic myeloproliferative diseases without the Philadelphia chromosome marker (Ph-), although first described 60 years ago, only became the subject of interest after the turn of the millennium. In 2001, the World Health Organization (WHO) defined the classification of this group of diseases and in 2008 they were renamed myeloproliferative neoplasms based on morphological, cytogenetic and molec...

Myeloproliferative Neoplasms other than Chronic Myeloid Leukemia - A Five Year Single Center Experience

National Institute of Blood Disease and Bone Marrow Transplantation Karachi, Pakistan *Corresponding Author’s Email: [email protected] Tel.: +923009370577 A retrospective analysis of 5 years data of myeloproliferative neoplasm (MPN) other than chronic myeloid leukaemia (CML) was done. All the cases were diagnosed and classified according to World Health Organization (WHO) Classification 2...

Effects of Mutational Combinations on Philadelphia-Negative Myeloproliferative Neoplasms

Molecular approach to diagnose BCR/ABL negative chronic myeloproliferative neoplasms

Chronic myeloproliferative neoplasms arise from clonal proliferation of hematopoietic stem cells. According to the World Health Organization myeloproliferative neoplasms are classified as: chronic myelogenous leukemia, polycythemia vera, essential thrombocythemia, primary myelofibrosis, chronic neutrophilic leukemia, chronic eosinophilic leukemia, hypereosinophilic syndrome, mast cell disease, ...