PGJ2, A New Antiviral Prostaglandin: Inhibition of Sendai Virus Replication and Alteration of Virus Protein Synthesis

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PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis.

Prostaglandin J2 (PGJ2) was found to suppress dramatically Sendai virus replication in African green monkey kidney cells in culture. PGJ2 was not toxic at the active dose to uninfected cells and did not significantly inhibit macromolecular synthesis, but it specifically stimulated the synthesis of a polypeptide of 74,000 mol. wt. In Sendai virus-infected cells, PGJ2 partially inhibited virus pr...

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ژورنال

عنوان ژورنال: Journal of General Virology

سال: 1987

ISSN: 0022-1317,1465-2099

DOI: 10.1099/0022-1317-68-4-1153