pFTAA - a high affinity oligothiophene probe that detects filamentous tau in vivo and in cultured neurons
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چکیده
منابع مشابه
pFTAA: a high affinity oligothiophene probe that detects filamentous tau in vivo and in cultured neurons
PERSPECTIVE pFTAA: a high affinity oligothiophene probe that detects filamentous tau in vivo and in cultured neurons Tauopathies describe a group of neurodegenerative diseases in which the protein tau, encoded by the gene MAPT, is aberrantly misfolded, leading to tau aggregation, neural dysfunction, and cell death (Spillantini and Goedert, 2013). In Alzheimer's disease (AD), tau forms the chara...
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Identification of fluorescent dyes that label the filamentous protein aggregates characteristic of neurodegenerative disease, such as β-amyloid and tau in Alzheimer's disease, in a live cell culture system has previously been a major hurdle. Here we show that pentameric formyl thiophene acetic acid (pFTAA) fulfills this function in living neurons cultured from adult P301S tau transgenic mice. I...
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15 صفحه اولHuman tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ.
Microinjection of plasmids encoding human tau (htau) protein into identified lamprey reticulospinal neurons (anterior bulbar cells, or ABCs) in situ induces chronic htau expression. htau protein is transported to both the axon and dendrites of expressing ABCs by mechanisms that require the C-terminal domain of htau protein but do not require directed htau mRNA transport. htau becomes phosphoryl...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2015
ISSN: 1673-5374
DOI: 10.4103/1673-5374.165298