PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression

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PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression.

How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear. Our previous studies suggest that PexRAP, a peroxisomal lipid synthetic enzyme, regulates PPARγ signaling and white adipogenesis. Here, we show that PexRAP is an inhibitor of brown adipocyte gene expression. Pe...

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ژورنال

عنوان ژورنال: Cell Reports

سال: 2017

ISSN: 2211-1247

DOI: 10.1016/j.celrep.2017.08.077