PEX16 contributes to peroxisome maintenance by constantly trafficking PEX3 via the ER

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PEX16 contributes to peroxisome maintenance by constantly trafficking PEX3 via the ER

The endoplasmic reticulum (ER) is required for the de novo biogenesis of peroxisomes in mammalian cells. However, its role in peroxisome maintenance is unclear. To explore ER involvement in the maintenance of peroxisomes, we redirect a peroxisomal membrane protein (PMP), PEX3, to directly target to the ER using the N-terminal ER signal sequence from preprolactin. Using biochemical techniques an...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2014

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.146282