منابع مشابه
A redox-mediated Kemp eliminase
The acid/base-catalysed Kemp elimination of 5-nitro-benzisoxazole forming 2-cyano-4-nitrophenol has long served as a design platform of enzymes with non-natural reactions, providing new mechanistic insights in protein science. Here we describe an alternative concept based on redox catalysis by P450-BM3, leading to the same Kemp product via a fundamentally different mechanism. QM/MM computations...
متن کاملKemp Eliminase Activity of Ketosteroid Isomerase.
Kemp eliminases represent the most successful class of computationally designed enzymes, with rate accelerations of up to 109-fold relative to the rate of the same reaction in aqueous solution. Nevertheless, several other systems such as micelles, catalytic antibodies, and cavitands are known to accelerate the Kemp elimination by several orders of magnitude. We found that the naturally occurrin...
متن کاملJALDA's Interview with Peter Mühlhäusler
Peter Mühlhäusler is the Foundation Professor of Linguistics at the University of Adelaide, and Supernumerary Fellow of Linacre College, Oxford. He has taught at the Technical University of Berlin and in the University of Oxford. He is an active researcher in several areas of linguistics, including ecolinguistics, language planning, and language policy and language contact in the Australian-Pac...
متن کاملPeter Marshall
This paper outlines and analyses the behaviours of small and medium enterprises with respect to the evaluation of electronic commerce investments, and the subsequent realisation of the anticipated benefits from those investments. The responses of executives who participated in the study suggested that on-going involvement in electronic commerce did not come cheaply. Nonetheless, our study sugge...
متن کاملPeter Leong
In recent times, games-based learning has been attracting the attention of educators around the world. One of the challenges in deploying games-based learning to cover a larger proportion of the curriculum is the high costs associated with development of the games. Games development often requires specialized skills sets. Inputs from academic specialists for the learning content and pedagogy is...
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ژورنال
عنوان ژورنال: WISDOM
سال: 2018
ISSN: 1829-3824
DOI: 10.24234/wisdom.v11i2.226