Pesticide mixture toxicity assessment through in situ and laboratory approaches using embryo-larval stages of the pacific oyster (Magallana gigas)

Worsened state of oysters in French Arcachon Bay, demand an investigation possible causes. This study evaluated the effects environmentally relevant mixture five common pesticides on early-life stages Pacific oyster (Magallana gigas). Laboratory assays with artificial and situ transplantation were complementarily used to investigate a series sublethal endpoints. The laboratory exposure revealed developmental toxicity at 0.32 μg/L, which corresponds concentrations Bay. Downregulation some gene transcriptions was observed environmental level. No difference larvae development among three sites first evaluate locomotion exposed situ. Suspected poor water quality inner part Bay reflected by impairment molecular In conclusion, current tested hinder larval affect several biological functions.