Pervasive Multinucleotide Mutational Events in Eukaryotes
نویسندگان
چکیده
منابع مشابه
Pervasive Multinucleotide Mutational Events in Eukaryotes
Many aspects of mutational processes are nonrandom, from the preponderance of transitions relative to transversions to the higher rate of mutation at CpG dinucleotides [1]. However, it is still often assumed that single-nucleotide mutations are independent of one another, each being caused by separate mutational events. The occurrence of multiple, closely spaced substitutions appears to violate...
متن کاملLife events and depression in children with pervasive developmental disorders.
To determine the role of life events in the occurrence of depression in children with pervasive developmental disorders (PDD), we compared 11 patients (DSM-III-R; 9 male; 2 female; M age: 11.0 years; M full-scale IQ: 75.3) with PDD and depression, with an age- and sex-matched control group of patients with PDD without depression (DSM-III-R; 9 male; 2 female; M age: 9.8 years; M full-scale IQ: 6...
متن کاملAn Active Architecture for Managing Events in Pervasive Computing Environments
Many dramatizations have depicted a fully automated home living environment, where actions and events are understood or even anticipated. While the realization of such environments requires innovations on many fronts, our current research focuses on the development of an active database subsystem to respond to events in a home. The architecture implements the well-known event-conditionaction (E...
متن کاملError-prone polymerase activity causes multinucleotide mutations in humans.
About 2% of human genetic polymorphisms have been hypothesized to arise via multinucleotide mutations (MNMs), complex events that generate SNPs at multiple sites in a single generation. MNMs have the potential to accelerate the pace at which single genes evolve and to confound studies of demography and selection that assume all SNPs arise independently. In this paper, we examine clustered mutat...
متن کاملPrevalence of Multinucleotide Replacements in Evolution of Primates and Drosophila
Evolution of sequences mostly involves independent changes at different sites. However, substitutions at neighboring sites may co-occur as multinucleotide replacement events (MNRs). Here, we compare noncoding sequences of several species of primates, and of three species of Drosophila fruit flies, in a phylogenetic analysis of the replacements that occurred between species at nearby nucleotide ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2011
ISSN: 0960-9822
DOI: 10.1016/j.cub.2011.05.013