Pertussis immunity in pregnant women and factors associated with seronegative status

Despite high level of vaccination coverage, pertussis remains a serious problem modern medicine. Pertussis cases are registered among infants, adolescents, and adults. Infants younger than three months age have the highest rate clinical course. Transplacental transfer pertussis-specific antibodies induce protection against infection. The available data regarding anti-pertussis antibody in pregnant women Russia remain sparce. To evaluate humoral immunity to Bordetella factors associated with seronegative status, we performed cross-sectional study 388 participants. SeroPertussis IgG (Israel) ELISA kit was used quantitate toxin/hemagglutinin. Binary logistic regression analysis assess status. median subjects 30 years old, more half which (51.3%) provided no verified so that their children will not receive transplacental anti-infectious immunity. Gestational significantly Compared tested during first trimester, participants third trimester pregnancy were likely be pertussis. odds being susceptible rose increased gestational period (p 0.01 for linear trend). Age, number pregnancies status revealed impact on significant differences between seropositive subjects. booster vaccinations preschool children, adolescents healthcare workers dealing neonates as well cocoon strategy necessary implemented protect infants