Personalised cancer management: closer, but not here yet

Closer but not there yet: models in child injury research.

Die—but not just yet

eterochromatin’s repressive hold on DNA transcription can only be relinquished when activators enter the nucleus. Or so the theory goes. But now Vanessa Witte, Andreas Baur (University of Erlangen, Germany), and colleagues find that a heterochromatin component can be pulled from the nucleus by both the HIV protein Nef and activated integrins. “This is a really new concept—that chromatin-associa...

Publicly reported physician ratings: here to stay but not yet ready for prime time.

Public reporting of physician performance—whether user-generated physician rating websites or metrics-driven, scientifically based performance reports—is a reality of health care today and is increasingly tied to high-stakes outcomes, including reimbursement and compensation. With the rise of the consumerism movement, more and more patients are proactive in choosing their providers and are incr...

On third base but not home yet.

565 IN 28 YEARS of a busy and rewarding medical career I have had the opportunity to work in three different environments during three distinct stages of my career and life. As with many other young professionals I had some reasonable knowledge about how and when I would get to first base (medical degree and specialty). However, I was not able to predict when or where the next stage would take ...

Consciousness: Here, There but Not Everywhere

The science of consciousness has made great strides by focusing on the behavioral and neuronal correlates of experience. However, correlates are not enough if we are to understand even basic neurological fact; nor are they of much help in cases where we would like to know if consciousness is present: patients with a few remaining islands of functioning cortex, pre-term infants, non-mammalian sp...