Persisting Mixed Cryoglobulinemia in Chikungunya Infection

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Persisting Mixed Cryoglobulinemia in Chikungunya Infection

BACKGROUND Chikungunya virus (CHIKV), an arbovirus, is responsible for a two-stage disabling disease, consisting of an acute febrile polyarthritis for the first 10 days, frequently followed by chronic rheumatisms, sometimes lasting for years. Up to now, the pathophysiology of the chronic stage has been elusive. Considering the existence of occasional peripheral vascular disorders and some unexp...

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Hepatitis C virus (HCV) chronic infection is recognized as the major cause of mixed cryoglobulinemia (MC). Its persistence represents a continuous stimulus for host immune system with production of circulating immune complexes (ICs), one-third of them with cryoprecipitate property. Several factors contribute to the biological activities of ICs, many of which are not completely known. Among them...

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Mixed cryoglobulinemia

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ژورنال

عنوان ژورنال: PLoS Neglected Tropical Diseases

سال: 2009

ISSN: 1935-2735

DOI: 10.1371/journal.pntd.0000374