Persistent Tyrosinemia Associated with Low Activity of Tyrosine Aminotransferase
نویسندگان
چکیده
منابع مشابه
Enhancement of rat brain tyrosine aminotransferase activity by cortisol.
Administration of cortisol to rats enhanced brain tyrosine:2-oxoglutarate aminotransferase activity by a mechanism excluding stabilization, but possibly involving enhanced synthesis, of the enzyme.
متن کاملSilent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma
Tyrosinemia type I (TYRSN1, TYR I) is caused by fumarylacetoacetate hydrolase (FAH) deficiency and affects approximately one in 100,000 individuals worldwide. Pathogenic variants in FAH cause TYRSN1, which induces cirrhosis and can progress to hepatocellular carcinoma (HCC). TYRSN1 is characterized by the production of a pathognomonic metabolite, succinylacetone (SUAC) and is included in the Re...
متن کاملA recombinant tyrosine aminotransferase from Trypanosoma cruzi has both tyrosine aminotransferase and alanine aminotransferase activities.
Tyrosine aminotransferase purified from epimastigotes of Trypanosoma cruzi displays an additional activity of alanine aminotransferase, absent in all other tyrosine aminotransferases characterized so far. Since the parasite's genome contains a high number of copies of the tyrosine aminotransferase gene, we could not rule out the possibility that two very similar proteins, with changed specifici...
متن کاملPseudoisozymes of hepatic tyrosine aminotransferase.
Dexamethasone, insulin, and serum induce an additive increase in the activity of tyrosine aminotransferase (L-tyrosine : Z-oxoglutarate aminotransferase, EC 2.6.1.5) in hepatoma cells in tissue culture. By the criteria of immunotitration, heat stability, and electrophoresis on polyacrylamide gels, we have shown previously that all three effecters increase the cellular concentration of the same ...
متن کاملTyrosine Aminotransferase PURIFICATION AND CHARACTERIZATION
Tyrosine aminotransferase was highly purified from rat livers in which the enzyme had been induced by a glucocorticoid hormone. The preparation eluted from a DEAEcellulose column as a single peak gave a single precipitin line by the Ouchterlony double diffusion precipitin reaction and sedimented as a single boundary in the ultracentrifuge with an s20,W of 5.9. A molecular weight of 91,000 was d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 1984
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198407000-00023