Persistent organochlorines, sedentary occupation, obesity and human male subfertility

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Persistent organochlorines, sedentary occupation, obesity and human male subfertility.

BACKGROUND Studies have suggested that the quality of human semen has been declining over recent decades, presumably because of lifestyle or environmental factors. METHODS Polychlorinated biphenyls and organochlorine pesticides were analysed in the plasma of 25 men with poor semen quality, 20 men with normal semen quality and idiopathic subfertility and 27 men with normal semen quality and fe...

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Male obesity and subfertility, is it really about increased adiposity?

The prevalence of overweight and obesity in reproductive-aged men is increasing worldwide, with >70% of men >18 years classified as overweight or obese in some western nations. Male obesity is associated with male subfertility, impairing sex hormones, reducing sperm counts, increasing oxidative sperm DNA damage and changing the epigenetic status of sperm. These changes to sperm function as a re...

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Prenatal Exposure to Persistent Organochlorines and Childhood Obesity in the U.S. Collaborative Perinatal Project

BACKGROUND In some previous studies, prenatal exposure to persistent organochlorines such as 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p´-DDE), polychlorinated biphenyls (PCBs), and hexachlorobenzene (HCB) has been associated with higher body mass index (BMI) in children. OBJECTIVE Our goal was to evaluate the association of maternal serum levels of β-hexachlorocyclohexane (β-HCH), p,p...

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Obesity or Overweight, a Chronic Inflammatory Status in Male Reproductive System, Leads to Mice and Human Subfertility

Obesity is frequently accompanied with chronic inflammation over the whole body and is always associated with symptoms that include those arising from metabolic and vascular alterations. On the other hand, the chronic inflammatory status in the male genital tract may directly impair spermatogenesis and is even associated with male subfertility. However, it is still unclear if the chronic inflam...

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Reversible male subfertility due to hyperthyroidism.

A 26-year-old man with a one-year history of attempted conception was referred to a male subfertility clinic. Two previous semen analyses had disclosed oligospermia with sperm counts of 11 x 109/1 on both occasions (figure). He had had classical symptoms of thyrotoxicosis for five years and 18 months earlier had been investigated for palpitations. Examination showed a diffuse goitre, tremor, an...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2005

ISSN: 1460-2350,0268-1161

DOI: 10.1093/humrep/deh569