Peroxisome Proliferator–Activated Receptors Modulate Proliferation and Angiogenesis in Human Endometrial Carcinoma

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Signaling and Regulation Peroxisome Proliferator–Activated Receptors Modulate Proliferation and Angiogenesis in Human Endometrial Carcinoma

Peroxisome proliferator-activated receptors (PPAR) and retinoid X receptors (RXR) are implicated in the development of several obesity-related cancers. Little is known of either the expression or function of PPARs and RXRs in endometrial cancer although this increasingly common disease is highly associated with both obesity and insulin resistance. We investigated the expression of PPAR and RXR ...

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Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma.

Peroxisome proliferator-activated receptors (PPAR) and retinoid X receptors (RXR) are implicated in the development of several obesity-related cancers. Little is known of either the expression or function of PPARs and RXRs in endometrial cancer although this increasingly common disease is highly associated with both obesity and insulin resistance. We investigated the expression of PPAR and RXR ...

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Peroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear hormone receptors acting as transcriptional factors, recently involved also in carcinogenesis. Present study was undertaken to evaluate the presence and subcellular localization of different PPAR isoforms (α, β, γ) in healthy endometrial tissue (n = 10) and endometrial carcinoma (FIGO I, endometrioides type, G1, n...

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ژورنال

عنوان ژورنال: Molecular Cancer Research

سال: 2011

ISSN: 1541-7786,1557-3125

DOI: 10.1158/1541-7786.mcr-11-0233