Peroxisome proliferator-activated receptors (PPARs) in dermatology
نویسندگان
چکیده
منابع مشابه
Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis
BACKGROUND Peroxisome proliferator-activated receptor (PPAR) alpha, betadelta and gamma are nuclear receptors activated by fatty acid metabolites. An anti-inflammatory role for these receptors in airway inflammation has been suggested. METHODS Nasal biopsies were obtained from 10 healthy volunteers and 10 patients with symptomatic allergic rhinitis. Nasal polyps were obtained from 22 patients...
متن کاملPeroxisome Proliferator-Activated Receptors (PPARs): Choreographers of Metabolic Gene Transcription
Nuclear receptors are ligand-activated transcription factors that regulate gene expression in response to small lipophilic compounds such as testosterone [androgen receptor (AR)], oxysterols [liver X receptor (LXR)], estrogen (ER), xenobiotics [pregnane X receptor (PXR)], retinoic acid (RAR), thyroid hormone (TR), bile acids [farnesoid X receptor (FXR)] and vitamin D (VDR). The peroxisome proli...
متن کاملPeroxisome proliferator-activated receptors and their relevance to dermatology.
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and are expressed in a variety of tissues including skin and cells of the immune system. They act as ligand-dependent transcription factors which heterodimerize with retinoid X receptors to allow binding to and activation of PPAR responsive genes. Through this mechanism, PPAR ligands can ...
متن کاملPeroxisome Proliferator-activated Receptors
Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-activated nuclear hormone receptor superfamily of transcription factors that includes receptors for steroids, thyroid hormone, retinoic acid, and vitamin D. Upon activation in the cytoplasm, PPARs heterodimerize with retinoid X receptors (RXR) and form a complex that translocates to the nucleus and regulates gene expr...
متن کاملExpression of the Peroxisome Proliferator-Activated Receptors (PPARs) in the Hepatic Stellate Cells
Email: Takeya Sato* [email protected]; Mitsuru Sato [email protected]; Mitsutaka Miura [email protected]; Nobuyo Higashi [email protected]; Da-Ren Wang [email protected]; Shinsuke Suzuki [email protected]; Katsuyuki Imai [email protected]; Naosuke Kojima [email protected]; Haruki Senoo [email protected] * Corresponding author
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ژورنال
عنوان ژورنال: Dermato-Endocrinology
سال: 2011
ISSN: 1938-1980
DOI: 10.4161/derm.15025