Peroxisome Proliferator-activated Receptor γ Thiazolidinedione Agonists Increase Glucose Metabolism in Astrocytes
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Peroxisome Proliferator-Activated Receptor Agonists: Do They Increase Cardiovascular Risk?
Cardiovascular disease is a major cause of morbidity and mortality among people with type 2 diabetes mellitus. The peroxisome proliferator-activated receptor (PPAR) agonists have a significant role on glucose and fat metabolism. Thiazolidinediones (TZDs) are predominantly PPARγ agonists, and their primary benefit appears to be the prevention of diabetic complications by improving glycemic contr...
متن کاملPeroxisome proliferator-activated receptor gamma agonists in renal disease.
Type 2 diabetes is a well recognised cause of chronic renal failure (CRF). Only few oral antidiabetic drugs can be used for treating type 2 diabetes in patients with CRF. Among them are repaglinide, a rapid-acting prandial insulin releaser, and peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, such as rosiglitazone and pioglitazone. These compounds are metabolised in the li...
متن کاملPeroxisome proliferator-activated receptor-γ agonists repress epithelial sodium channel expression in the kidney.
Thiazolidinediones (TZDs), known as peroxisome proliferator-activated receptor (PPAR) agonists, are used to treat type 2 diabetes. However, ∼5% of patients experience the treatment-limiting side effect of edema. Studies have implicated activation of the epithelial sodium channel (ENaC) as a cause of TZD-induced fluid retention, although there have been conflicting reports. The goal of this stud...
متن کاملRole of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutrophils, which all express peroxisome proliferator-activated receptor-γ (PPAR-γ). PPAR-γ is a nucl...
متن کاملPeroxisome Proliferator-Activated Receptor Agonists Increase Nitric Oxide Synthase Expression in Vascular Endothelial Cells
Kayoko Goya, Satoru Sumitani, Xin Xu, Tetsuhiro Kitamura, Hiroyasu Yamamoto, Shogo Expression in Vascular Endothelial Cells Agonists Increase Nitric Oxide Synthase α Peroxisome Proliferator-Activated Receptor Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2004 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m208132200