Perivascular osteoprogenitors are associated with transcortical channels of long bones

Progesterone-responsive Osteoprogenitors Are Regulated by Estrogen and Distinct from Glucocorticoid-responsive Osteoprogenitors

Postmenopausal bone loss is clearly associated with a deficiency of sex steroids (1), and estrogen replacement therapy prevents it (2). Progesterone (Prog) deficiency could also be a factor, and Prog replacement therapy has indeed been shown to prevent postmenopausal bone loss and bone loss associated with ovarian dysfunction (3). In the osteoprogenitor assay system that we developed, morpholog...

Distinct adipocyte progenitor cells are associated with regional phenotypes of perivascular aortic fat in mice

OBJECTIVE Perivascular adipose tissue depots around the aorta are regionally distinct and have specific functional properties. Thoracic aorta perivascular adipose tissue (tPVAT) expresses higher levels of thermogenic genes and lower levels of inflammatory genes than abdominal aorta perivascular adipose tissue (aPVAT). It is not known whether this distinction is due to the in-vivo functional env...

Resection of the Long Bones

Docosahexaenoic acid is associated with endosteal circumference in long bones in young males with cystic fibrosis.

In children, but not adults with cystic fibrosis (CF), associations between essential fatty acids (FA) and bone mass have been reported. Low bone mineral density (BMD) is common in these patients. Previously we found a normal annual increase of BMD, suggesting a potential for attaining normal bone mass. The aim of the present study was to investigate phospholipid FA pattern in relation to bone ...

Retinal Microvascular Calibers Are Associated With Enlarged Perivascular Spaces in the Brain.

BACKGROUND AND PURPOSE Perivascular enlargement in the brain is a putative imaging marker for microvascular brain damage, but this link has not yet been confirmed using direct in vivo visualization of small vessels. We investigated the relation between microvascular calibers on retinal imaging and enlarged perivascular spaces (ePVSs) on brain magnetic resonance imaging. METHODS We included 70...