Peripheral Taenia infection increases immunoglobulins in the central nervous system

Human cysticercosis is a disease caused by larvae of the cestode Taenia solium. It an important common cause adult-onset seizures world-wide where it exacts debilitating toll on health and well-being affected communities. commonly assumed that major symptoms associated with are result direct presence in brain. As result, possible effects peripherally located central nervous system not well understood. To address this question, we utilised crassiceps intra-peritoneal murine model cysticercosis, restricted to peritoneal cavity. In model, previous research has observed behavioural changes rodents but development seizures. Here used ELISAs, immunoblotting Evans Blue test for blood–brain barrier permeability explore peripheral infection mice T. crassiceps. We identified high levels parasite-targeting immunoglobulins sera crassiceps-infected mice. show crassciceps themselves also contain release host over time. Additionally, describe, first known time, significantly increased IgG within hippocampi infected mice, which accompanied permeability. However, these crassiceps-induced were alterations proinflammatory, pro-seizure cytokines hippocampus. These findings contribute understanding systemic neuroimmune responses implications pathogenesis human cysticercosis.