Peripheral Blood CD8+ T-Lymphocyte Subsets Are Associated with Prognosis in Prostate Cancer Patients

Background: Various studies have reported associations between frequencies of total peripheral blood lymphocytes and prostate cancer prognosis, but none so far has addressed the prognostic role CD8+ T-lymphocyte subsets. Methods: A 43 patients with metastatic disease 81 non-metastatic were included in this study. Flow cytometry analyses employed for determining Results: Statistically significant lower levels terminally differentiated effector (TEMRA) cells vs. observed. Central memory (CM) (EM) subsets, found to be significantly higher disease. similar profile was revealed when these subsets analyzed based on patients’ Gleason scores, as well by combined stage (i.e., disease) score. Conclusions: Peripheral blood-derived could function biomarkers prognosis PCa.