Peripheral blood biomarkers in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Peripheral blood monocytes in multiple sclerosis exacerbations
Objectives: Monocytes (MO), macrophages, and microglia have a central role in the central nervous system inflammation of multiple sclerosis (MS). During clinical activity in MS, MO activation markers increase and some interleukins and tumor necrosis factor-alpha levels are elevated. Our aim was to determine levels of absolute MO count and percentage in peripheral blood of MS patients during the...
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Background: Multiple sclerosis (MS) is a T cell mediated autoimmune disease with unknown etiology. Appropriate MS therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. Ligation of TLR-2 and TLR-4 stimulates the production of several cytokines leading to CNS autoimmunity and neurodegenerative diseases. Objective: To find a relationship between M...
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BACKGROUND Amyotrophic lateral sclerosis (ALS) is a fatal progressive motor neuron disease, for which there are still no diagnostic/prognostic test and therapy. Specific molecular biomarkers are urgently needed to facilitate clinical studies and speed up the development of effective treatments. METHODOLOGY/PRINCIPAL FINDINGS We used a two-dimensional difference in gel electrophoresis approach...
متن کاملBiomarkers in Multiple Sclerosis
Roland Martina, Bibiana Bielekovab, Reinhard Hohlfeldc and Ursula Utzd,∗ Catalan Institute for Research and Advanced Studies and Unidad de Neuroimmunologia Clinica, Hospital Universitari Vall d’Hebron, Barcelona, Spain Department of Neurology, Waddel Center for MS, University of Cincinnati & The Neuroscience Institute, Cincinnati, OH, USA Department of Neuroimmunology, Max-Planck-Institute of N...
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Blood-brain barrier (BBB) disruption is one of the hallmarks of multiple sclerosis (MS). It is incompletely understood whether BBB disruption is the initial MS event leading to MS lesion formation or whether it is merely a consequence of cellular infiltration in the central nervous system (CNS). The presence of gadolinium enhancing (Gd+) lesions on serial brain MRI scans is frequently used to e...
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ژورنال
عنوان ژورنال: Autoimmunity Reviews
سال: 2015
ISSN: 1568-9972
DOI: 10.1016/j.autrev.2015.07.014