Peripartum changes in the orexigenic CNS peptide neuropeptide-Y in gestational diabetics
نویسندگان
چکیده
منابع مشابه
Peripartum changes in the orexigenic CNS peptide neuropeptide-Y in gestational diabetics
Background: Development of relative insulin resistance during pregnancy is a normal physiologic change related to placental lactogen and pregnancy-associated elevated lipid concentrations. Several studies have investigated the role of tissue response, tyrosine kinase insulin receptor phosphorylation, and other cytokines that might contribute to development of such resistance. In this study, we ...
متن کاملIdentification of potent and selective neuropeptide Y Y(1) receptor agonists with orexigenic activity in vivo.
Neuropeptide Y (NPY) binds to a family of G-protein coupled receptors termed Y(1), Y(2), Y(3), Y(4), Y(5), and y(6). The use of various receptor subtype-selective agonists and antagonists has facilitated identification of the receptor subtypes responsible for mediating many of the biological effects of NPY. For example, the potent orexigenic activity of NPY is believed to be mediated by both th...
متن کاملNeuropeptide Y and its role in CNS disease and repair.
Neuropeptide Y (NPY) is widely expressed throughout the CNS and exerts a number of important physiological functions as well as playing a role in pathological conditions such as obesity, anxiety, epilepsy, chronic pain and neurodegenerative disorders. In this review, we highlight some of the recent advances in our understanding of NPY biology and how this may help explain not only its role in h...
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In bullfrog larvae at the pre- and pro-metamorphic stages, feeding behavior is regulated by appetite factors such as orexigenic peptides. In fact, food intake is enhanced by intracerebroventricular (ICV) administration of neuropeptide Y (NPY) and orexin A. Using goldfish, our previous study indicated that the orexigenic action of NPY is mediated by orexin A, suggesting the functional interactio...
متن کاملDouble deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.
OBJECTIVE Orexigenic neuropeptide Y (NPY) and dynorphin (DYN) regulate energy homeostasis. Single NPY or dynorphin deletion reduces food intake or increases fat loss. Future developments of obesity therapeutics involve targeting multiple pathways. We hypothesised that NPY and dynorphin regulate energy homeostasis independently, thus double NPY and dynorphin ablation would result in greater weig...
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ژورنال
عنوان ژورنال: Journal of Diabetes Research and Clinical Metabolism
سال: 2013
ISSN: 2050-0866
DOI: 10.7243/2050-0866-2-23